Liste des publications

2022

• Design and in vitro characterization of RXR variants as tools to investigate the biological role of endogenous rexinoids

  le Maire A, Rey M, Vivat V, Guee L, Blanc P, Malosse C, Chamot-Rooke J, Germain P, Bourguet W, J Mol Endocrinol, 2022

2021

• Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR)

  Senicourt L, le Maire A, Allemand F, Carvalho JE, Guee L, Germain P, Schubert M, Bernado P, Bourguet W, Sibille N, J Mol Biol, 2021

2020

• Two Novel Cases of Resistance to Thyroid Hormone Due to

  le Maire A, Bouhours-Nouet N, Soamalala J, Mirebeau-Prunier D, Paloni M, Guee L, Heron D, Mignot C, Illouz F, Joubert F, Briet C, Rodien P, Bourguet W, Flamant F, Guyot R, Thyroid, 2020

• PPARgamma S273 Phosphorylation Modifies the Dynamics of Coregulator Proteins Recruitment

  Dias MMG, Batista FAH, Tittanegro TH, de Oliveira AG, Le Maire A, Torres FR, Filho HVR, Silveira LR, Figueira ACM, Front Endocrinol (Lausanne), 2020

• IDPs and their complexes in GPCR and nuclear receptor signaling

  Guillien M, le Maire A, Mouhand A, Bernado P, Bourguet W, Baneres JL, Sibille N, Prog Mol Biol Transl Sci, 2020

• Protein-protein interactions in the regulation of RAR-RXR heterodimers transcriptional activity

  le Maire A, Germain P, Bourguet W, Meth Enzymol, 2020

2019

• Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations

  le Maire A, Teyssier C, Balaguer P, Bourguet W, Germain P, Cells, 2019

• Exploring the mechanism of PPARgamma phosphorylation mediated by CDK5

  Ribeiro Filho HV, Guerra JV, Cagliari R, Batista FAH, Le Maire A, Oliveira PSL, Figueira ACM, J Struct Biol, 2019

• Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression

  Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernado P, Structure, 2019

2018

• Pathological interactions between mutant thyroid hormone receptors and corepressors and their modulation by a thyroid hormone analogue with therapeutic potential

  Harrus D, Demene H, Vasquez EF, Boulahtouf A, Germain P, Figueira AC, Privalsky ML, Bourguet W, le Maire A, Thyroid, 2018

• Screening for PPAR Non-Agonist Ligands Followed by Characterization of a Hit, AM-879, with Additional No-Adipogenic and cdk5-Mediated Phosphorylation Inhibition Properties

  Ribeiro Filho HV, Bernardi Videira N, Bridi AV, Tittanegro TH, Helena Batista FA, de Carvalho Pereira JG, de Oliveira PSL, Bajgelman MC, Le Maire A, Figueira ACM, Front Endocrinol (Lausanne), 2018

2016

• The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity

  Mas-Y-Mas S, Barbon M, Teyssier C, Demene H, Carvalho JE, Bird LE, Lebedev A, Fattori J, Schubert M, Dumas C, Bourguet W, Le Maire A, PLoS One, 2016

2015

• Molecular mechanisms of transcriptional control by Rev-erbalpha: An energetic foundation for reconciling structure and binding with biological function

  Vaissiere A, Berger S, Harrus D, Dacquet C, Le Maire A, Boutin JA, Ferry G, Royer CA, Protein Sci, 2015

2014

• Nuclear receptor profiling of bisphenol-a and its halogenated analogues

  Delfosse V, Grimaldi M, le Maire A, Bourguet W, Balaguer P, Vitam Horm, 2014

• Retinoic Acid receptors: structural basis for coregulator interaction and exchange

  le Maire A, Bourguet W, Subcell Biochem, 2014

2012

• Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes

  Delfosse V, Grimaldi M, Pons JL, Boulahtouf A, le Maire A, Cavailles V, Labesse G, Bourguet W, Balaguer P, Proc Natl Acad Sci U S A, 2012

2011

• In-plate protein crystallization, in situ ligand soaking and X-ray diffraction

  le Maire A, Gelin M, Pochet S, Hoh F, Pirocchi M, Guichou JF, Ferrer JL, Labesse G, Acta Crystallogr D Biol Crystallogr, 2011

• Peroxisome proliferator-activated receptor gamma is a target for halogenated analogs of bisphenol A

  Riu A, Grimaldi M, le Maire A, Bey G, Phillips K, Boulahtouf A, Perdu E, Zalko D, Bourguet W, Balaguer P, Environ Health Perspect, 2011

• Characterization of novel ligands of ERalpha, Erbeta, and PPARgamma: the case of halogenated bisphenol A and their conjugated metabolites

  Riu A, le Maire A, Grimaldi M, Audebert M, Hillenweck A, Bourguet W, Balaguer P, Zalko D, Toxicol Sci, 2011

2010

• A structural view of nuclear hormone receptor: endocrine disruptor interactions

  le Maire A, Bourguet W, Balaguer P, Cell Mol Life Sci., 2010

• A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor

  le Maire A, Teyssier C, Erb C, Grimaldi M, Alvarez S, de Lera AR, Balaguer P, Gronemeyer H, Royer CA, Germain P, Bourguet W, Nat Struct Mol Biol, 2010

2009

• Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors

  le Maire A, Grimaldi M, Roecklin D, Dagnino S, Vivat-Hannah V, Balaguer P, Bourguet W, EMBO Rep, 2009